Download e-book for iPad: Advances in Plant Glycosides, Chemistry and Biology, by Chong-Ren Yang, Osamu Tanaka

By Chong-Ren Yang, Osamu Tanaka

ISBN-10: 0080544541

ISBN-13: 9780080544540

ISBN-10: 0444501800

ISBN-13: 9780444501806

Hardbound. within the plant country quite a few chemical parts take place in a glycoside shape (conjugation with sugar). Glycosides are very important, secondary metabolites. The structural range is because of the the mammoth volume of types and stereochemical configurations of the sugar part. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, different uncomplicated phenolics, and isothiocyanate. despite the fact that, organic actions of glycosides are, in lots of instances, vulnerable to the character of sugar moieties, even supposing their aglycone is the same.Since the 80s, plant glycosides were attracting an expanding quantity of curiosity from botanists and phytochemists world-wide for the next purposes: - they're tough to isolate and purify- they've got a vital organic functionality in vegetation and noteworthy organic actions- they're a vitally important source of common drugs, overall healthiness nutrients, cosmetics and f

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Notoginseng on two-stage carcinogenesis of mouse skin tumor under pre-treatment and post-treatment, using dimethylbenz- [a]anthracene (DMBA) as an initiator and TPA as a promoter, were investigated. The rate (%) of papilloma-bearing mice (Fig. 3-A) and the average number of papillomas per mouse (Fig. 3-B) of treated group were compared with those of the positive control group. In the positive control group, 80% of mice bore papillomas at 8 weeks of promotion and 100% of mice bore papillomas at 10 weeks of promotion, and more than 10 papillomas were formed per mouse atter 20 weeks of promotion.

O. ~"" . oleanolic acid 3-O-8]ucuronide(30) ,,,HO-,----rH OH , '.. . . momordin Ic (32) [ Acylated Olean-12-ene 3-O-Monodesmoside I Aesculus hippocastanum, A. 0--0 H ~',,O~C-OH ~ = ~20H ~ 3 Polygala senega var. Iatifolia (senegasaponins,Z - s e n e g ~ ,,,,, HO1. ~. ~~I J L~I . L - - v J OH2OH O0 CH20H OO 0 H6~DH FILl OH R escin Ia (43)" R=CH2OH escin IIa (44): R=H E,Z-senegin II (45) HO 0~ HO-~'rH OH 00 [H O I H ]"mlr H OHHO OH OH Chart 5 As our continuing studies to find the saponin constituents with inhibitory activity of 25 glucose absorption, we have found the saponin fractions of several medicinal foodstuffs and natural medicines to show the inhibitory activity on the increase of serum glucose levels in glucose-loaded rats(Table 2).

Notoginseng, and especially, ginsenoside-Rb 1, -Rb2, -Rd, -Re and -Rgl have been isolated as major neutral saponins. Furthermore, acetylene derivatives, panaxytriol and panaxynol have been also isolated from this plant. Therefore, these saponins and acetylenes were assayed on EBV-EA activation, and these results are shown in Table 2. Table 2. 0 (>80) Sample Concentration(mol ratio, compound/TPA) lx 103 lx 103 5x 10 lx 10 1 panaxytriol .... c (0) .... c (0) .... 9 (>80) panaxynol .... c (0) ....

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Advances in Plant Glycosides, Chemistry and Biology, Proceedings of the International Symposium in Plant Glycosides by Chong-Ren Yang, Osamu Tanaka


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