Arachidonate Remodeling and Inflammation - download pdf or read online

By Alfred N. Fonteh (auth.), Alfred N. Fonteh, Robert L. Wykle (eds.)

ISBN-10: 3034878486

ISBN-13: 9783034878487

ISBN-10: 3034895941

ISBN-13: 9783034895941

Arachidonic acid (AA) and different 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of irritation referred to as eicosanoids. those mediators are severe in sickness approaches and in regulating general phone functionality. home improvement is necessary in protecting homeostasis and in regulating mobile functionality through dictating how PUFAs are switched over to lipid mediators of irritation. therefore, PUFA home improvement is a severe strategy within the biosynthesis of a mess of mediators, and knowing this strategy will get to the bottom of higher healing objectives for controlling inflammatory ailments akin to bronchial asthma and Alzheimer’s disease.
AA metabolism is defined in an built-in context linking the transforming techniques with the biosynthesis of mediators and ailments. through following the move of the substrate (AA), the amount describes how upstream biosynthetic pathways impact the formation of lipid mediators of irritation, displaying the metabolic interrelationship among all AA-derived mediators.

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Additional info for Arachidonate Remodeling and Inflammation

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Recently demonstrated that PGD 2 and PGlz suppress cyclin Dl expression through their association with PPAR-y [134]. 1 12 ,14 prostaglandin h (15-deoxy PGh). These bioadive lipids are known to down-regulate the expression of cyclin 01 and other proteins that are essential for progression from G1 to S phase and thereby to limit cell cycle progression. gene. Together, these data suggest that a cell's ability to generate prostanoids can have a major impact on its ability to proliferate. As prostanoids are derived from arachidonic acid, this in turn suggests that cell growth and viability are linked to the acyl chain composition of glycerophospholipid.

J Membr Bioi 48: 215-236 100 Brown DA, London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Bioi 14: 111-136 101 Venable ME, Zimmerman GA, Mcintyre TM, Prescott SM (1993) Platelet-activating factor: A phospholipid autacoid with diverse actions. J Lipid Res 34: 691-702 102 Naraba H, Imai Y, Kudo I, Nakagawa Y, Oh-ishi S (1995) Activation of phospholipase A2 and acylation of lysophospholipids: The major regulators for platelet activating factor production in rat neutrophils.

However, several of the biological functions described above cannot be easily reconciled with enzymatic activity alone. For example, intradermal injection of inactivated sPLA2 causes similar phenotypic changes in skin to those observed when the fully active enzyme was injected [131]. Similarly, others have shown that the physiologic action of sPLA 2 is not due to hydrolytic activity [125, 132]. We have demonstrated that very low concentrations of sPLA2 (low nanomolar levels) of certain sPLA2 isotypes induce AA release, histamine release, and proliferation of some cells and enhance the survival of other cells in a receptor-mediated fashion [82].

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Arachidonate Remodeling and Inflammation by Alfred N. Fonteh (auth.), Alfred N. Fonteh, Robert L. Wykle (eds.)


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